Title: Using protein engineering, antibody evolution and small-molecule discovery to dissect host-pathogen interactions
Key words: Protein engineering, viral evolution, host-pathogen interactions, small-molecule discovery
Our research focuses on the...
Retroviruses are associated with a wide range of clinical diseases, including leukemia, tumors, and acquired immunodeficiency syndrome. Human immunodeficiency virus (HIV) is an exceptionally deadly retrovirus that has caused more than 20 million deaths...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
We are interested in the mechanisms that direct development and degeneration of the central nervous system (CNS) of vertebrates. We are focusing our studies on the vertebrate retina, a relatively simple and well-characterized area of the CNS. We have used...
Our laboratory studies the mechanisms of epigenetic regulation of DNA virus infection. We are interested in the mechanisms by which human cells sense foreign DNA in the cell nucleus and activate transcription of innate response genes and epigenetically...
Question
How can we measure the structures of RNAs in the cell? How does RNA regulate gene expression in normal cells, and what aspects go awry in the onset of disease states such as viral infections, neurodegeneration and cancer?
Approach
RNA viruses have...
Antigen-Specific Basis of Autoimmunity and Cancer
The Kohlgruber lab investigates the antigen-specific basis of human diseases and applies high-throughput molecular, genetic, and immunological assays to decipher immune system specificities and...
The role of Merkel cell polyomavirus in Merkel cell carcinoma
Merkel cell carcinoma is a skin cancer with a high rate of mortality. Factors that increase the risk for developing MCC include excessive exposure to sunlight, advanced age and an...
Overview
The Wesemann laboratory uses mouse genetics, human studies, cellular biology, single cell transcriptomics, and computation to elucidate underlying features and elasticity of antibody recognition capacity. We study the dynamic regulation...
The gamma-herpesvirus Epstein Barr virus (EBV) is a master regulator of B-cell biology. EBV persistently infects >95% of adults, making it one of the most successful viruses worldwide. While EBV typically establishes a safe balance with the host, it is...
