Faculty
Sun Hur
sun.hur@crystal.harvard.eduProfessor of Biological Chemistry and Molecular Pharmacology
Elucidating the Molecular Principles of Self vs Non-self RNA Discrimination by the Immune System Correct discrimination of “self” vs “non-self” nucleic acids by the innate immune system is essential for host defense against viral infection. A failure to...
Sizun Jiang
sjiang3@bidmc.harvard.eduAssociate Professor of Medicine
We seek to develop and apply technologies (particularly revolving around high-dimensional tissue imaging) to address questions related to host-disease interactions in their native tissue context. By combining these methodologies with a systems approach to...
Cigall Kadoch
cigall_kadoch@dfci.harvard.eduAssociate Professor, Department of Pediatric Oncology
Our laboratory research program is centered in understanding the structure and function of ATP-dependent chromatin remodeling complexes, with emphasis on the mammalian SWI/SNF (mSWI/SNF or BAF) family of assemblies. Using a multidisciplinary set of...
Jonathan C. Kagan
jonathan.kagan@childrens.harvard.eduMarian R. Neutra, PhD Professor of Pediatrics
Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger the activation of anti-microbial defenses. All PRRs, which evolved to detect potentially pathogenic...
Kenneth Marc Kaye
kkaye@rics.bwh.harvard.eduProfessor of Medicine
Our laboratory investigates Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8). KSHV has a causative role in Kaposi's sarcoma, primary effusion lymphomas and multicentric Castleman's disease, an aggressive lymphoproliferative...
Dennis Kim
dennis.kim@childrens.harvard.eduR. Cannon Eley, MD Professor of Pediatrics
Our studies have spanned evolutionarily conserved pathways of innate immunity, the integrative physiology that connects infection and immunity with cellular and organismal responses to stress, and how interactions with microbes influence neuronal...
Tomas L. Kirchhausen
kirchhausen@crystal.harvard.eduProfessor of Cell Biology
Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular our studies have help define molecular mechanisms that underlie the cell's sorting machineries mediated by the clathrin...
David Mahan Knipe
david_knipe@hms.harvard.eduProfessor of Microbiology
Our laboratory studies the mechanisms of epigenetic regulation of DNA virus infection. We are interested in the mechanisms by which human cells sense foreign DNA in the cell nucleus and activate transcription of innate response genes and epigenetically...
Ayano Kohlbruber
Ayano.Kohlgruber@childrens.harvard.eduAssistant Professor of Pediatrics
Antigen-Specific Basis of Autoimmunity and Cancer The Kohlgruber lab investigates the antigen-specific basis of human diseases and applies high-throughput molecular, genetic, and immunological assays to decipher immune system specificities and...
Philip J. Kranzusch
philip_kranzusch@dfci.harvard.eduAssociate Professor of Microbiology
We are working to understand how cells respond to pathogens, and how these signaling pathways can be harnessed for new potential therapies to treat cancer and autoimmune diseases. Importantly, many critical aspects of the cellular response to infection...
Daniel Kuritzkes
dkuritzkes@partners.orgHarriet Ryan Albee Professor of Medicine
1. Resistance to antiretroviral drugs For many HIV-infected patients, the potential benefits of antiretroviral therapy are limited by emergence of drug-resistant virus. Work in my laboratory is directed towards understanding mechanisms of resistance to...
Jérémie Le Pen
jlepen@hsph.harvard.eduAssistant Professor of Immunology and Infectious Diseases
Our lab focuses on innate immunity to RNA viruses. The genomes of humans and other animals harbor genes that have naturally evolved to combat viral infections and promote health. Our goal is to identify these antiviral strategies shaped by nature and...
