Faculty

Arlene Sharpe

Chair & Kolokotrones University Professor
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
Photo of Arlene Sharpe

Jonathan Abraham

Associate Professor of Microbiology
We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed at treating or preventing infection. Several enveloped RNA viruses cause human viral hemorrhagic...
Jonathan Abraham

Alejandro Benjamin Balazs

Assistant Professor of Medicine
My laboratory employs approaches rooted in synthetic immunology as a means of engineering or enhancing the natural immune system with the goal of understanding, preventing and treating HIV infection. We are currently applying these approaches to a number...
Alejandro Balazs

Dan Hung Barouch

William Bosworth Castle Professor of Medicine
Dan Barouch received his Ph.D. in immunology from Oxford University and his M.D. from Harvard Medical School. He is currently the William Bosworth Castle Professor of Medicine at Harvard Medical School, Director of the Center for Virology and Vaccine...
Man in a blue suit jacket and tie smiles at the camera

Constance L. Cepko

Bullard Professor of Genetics and Neuroscience
We are interested in the mechanisms that direct development and degeneration of the central nervous system (CNS) of vertebrates. We are focusing our studies on the vertebrate retina, a relatively simple and well-characterized area of the CNS. We have used...
Constance Cepko

Bing Chen

Rosalind Franklin, PhD Professor of Pediatrics
Our research centers on elucidating molecular mechanisms of HIV (human immunodeficiency virus) viral entry -- that is, how HIV enters host cells and how the viral envelope protein interacts with host cellular receptors. Insights gained from these studies...
Bing Chen

Raymond Taeyong Chung

Professor of Medicine
Our laboratory has been focused on the mechanisms of HCV persistence and pathogenesis. Hepatitis C virus infects 170 million persons worldwide and is remarkable for its predilection for chronicity. It is also a leading cause of chronic liver disease...
Raymond Chung

George Mcdonald Church

Robert Winthrop Professor of Genetics
Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the...
George Church

Kizzmekia Corbett

Assistant Professor of Immunology and Infectious Diseases
Dr. Corbett uses her viral immunology expertise to propel novel vaccine development for pandemic preparedness, including mRNA-1273, a leading vaccine against SARS-CoV-2. The vaccine concept incorporated in mRNA-1273 was designed by Dr. Corbett's NIH team...
Kizzmekia Corbett

James Morgan Cunningham

Associate Professor of Medicine (Microbiology and Molecular Genetics)
My laboratory is interested in the pathogenesis of virus-induced leukemia. In particular, we study the mechanism of infection by retroviruses that cause leukemia in mice. As part of these studies, we have identified the receptors that these viruses use to...
James Cunningham

Alan David D'Andrea

Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology
Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by germline or somatic mutation, leads to genomic instability, cellular sensitivity to ionizing radiation...
Alan D'Andrea

Victoria D'Souza

Professor of Molecular and Cellular Biology
Retroviruses are associated with a wide range of clinical diseases, including leukemia, tumors, and acquired immunodeficiency syndrome. Human immunodeficiency virus (HIV) is an exceptionally deadly retrovirus that has caused more than 20 million deaths...
Victoria D'Souza