Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic...
1. Resistance to antiretroviral drugs
For many HIV-infected patients, the potential benefits of antiretroviral therapy are limited by emergence of drug-resistant virus. Work in my laboratory is directed towards understanding mechanisms of resistance to...
Research in the Engelman laboratory focuses on the integration step in the retroviral life cycle. In order to replicate, retroviruses must integrate the viral DNA (vDNA) product of reverse transcription into a host cell chromosome. In addition to the...
Our lab studies molecular mechanisms of HIV replication and pathogenesis, and their role in mediating pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, metabolomic, systems biology, and...
We seek to develop and apply technologies (particularly revolving around high-dimensional tissue imaging) to address questions related to host-disease interactions in their native tissue context. By combining these methodologies with a systems approach to...
I am the Director of the Harvard/Brigham Virology Specialty Laboratory and the Director of the Harvard University Center for AIDS Research Clinical Core. My research is focused on HIV and SARS-CoV-2 drug resistance, reservoirs, and viral remission...
The Zhuang research lab uses advanced optical imaging techniques to study the behavior of individual biological molecules and complexes in vitro and in live cells. Our current research is focused on the following three major directions.
Super-resolution...
The Vandenberghe laboratory deconstructs viral evolution to improve viral vector design and use in gene therapy. We aim to more profoundly understand capsid structure-function relationships and use this information to select and engineer gene therapy...
