The Vandenberghe laboratory deconstructs viral evolution to improve viral vector design and use in gene therapy. We aim to more profoundly understand capsid structure-function relationships and use this information to select and engineer gene therapy...
Our laboratory is interested in the development of herpes simplex virus (HSV) vectors for cancer therapy, with the long-term goal of translating these vectors to the clinic, and strategies to target cancer stem cells. Oncolytic (replication-competent)...
My lab works at the intersection of virology, immunology and systems biology. Our core mission is to uncover global principles in virology by decoding hundreds of viral genomes. Our projects revolve around a central question: how have the compact genomes...
Michael Farzan’s laboratory focuses on the generation and delivery of antibodies and antibody-like entry inhibitors for the prevention and treatment of infectious diseases, especially those caused by coronaviruses, arenaviruses, and retroviruses. We are...
My laboratory employs approaches rooted in synthetic immunology as a means of engineering or enhancing the natural immune system with the goal of understanding, preventing and treating HIV infection. We are currently applying these approaches to a number...
We are interested in the mechanisms that direct development and degeneration of the central nervous system (CNS) of vertebrates. We are focusing our studies on the vertebrate retina, a relatively simple and well-characterized area of the CNS. We have used...
Dan Barouch received his Ph.D. in immunology from Oxford University and his M.D. from Harvard Medical School. He is currently the William Bosworth Castle Professor of Medicine at Harvard Medical School, Director of the Center for Virology and Vaccine...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Our laboratory investigates Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8). KSHV has a causative role in Kaposi's sarcoma, primary effusion lymphomas and multicentric Castleman's disease, an aggressive lymphoproliferative...
Our laboratory studies the mechanisms of epigenetic regulation of DNA virus infection. We are interested in the mechanisms by which human cells sense foreign DNA in the cell nucleus and activate transcription of innate response genes and epigenetically...
