A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic...
The gamma-herpesvirus Epstein Barr virus (EBV) is a master regulator of B-cell biology. EBV persistently infects >95% of adults, making it one of the most successful viruses worldwide. While EBV typically establishes a safe balance with the host, it is...
We seek to develop and apply technologies (particularly revolving around high-dimensional tissue imaging) to address questions related to host-disease interactions in their native tissue context. By combining these methodologies with a systems approach to...
Our body is colonized by a robust and diverse ecosystem - the commensal microbiome. When mucosal pathogens infect us, they first encounter our commensals before they encounter and activate our immune response. The Gopinath lab is interested in the...
The Vandenberghe laboratory deconstructs viral evolution to improve viral vector design and use in gene therapy. We aim to more profoundly understand capsid structure-function relationships and use this information to select and engineer gene therapy...
Our research centers on defining how germline B cell antigen recognition controls epitope targeting in the downstream antibody response. We focus on how gene-encoded ‘pattern' recognition motifs within the antibody repertoire naturally support recognition...
Our laboratory studies the mechanisms of epigenetic regulation of DNA virus infection. We are interested in the mechanisms by which human cells sense foreign DNA in the cell nucleus and activate transcription of innate response genes and epigenetically...
