Our laboratory is interested in the development of herpes simplex virus (HSV) vectors for cancer therapy, with the long-term goal of translating these vectors to the clinic, and strategies to target cancer stem cells. Oncolytic (replication-competent)...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
Research in the Engelman laboratory focuses on the integration step in the retroviral life cycle. In order to replicate, retroviruses must integrate the viral DNA (vDNA) product of reverse transcription into a host cell chromosome. In addition to the...
Our laboratory research program is centered in understanding the structure and function of ATP-dependent chromatin remodeling complexes, with emphasis on the mammalian SWI/SNF (mSWI/SNF or BAF) family of assemblies. Using a multidisciplinary set of...
The Zhuang research lab uses advanced optical imaging techniques to study the behavior of individual biological molecules and complexes in vitro and in live cells. Our current research is focused on the following three major directions.
Super-resolution...
The Vandenberghe laboratory deconstructs viral evolution to improve viral vector design and use in gene therapy. We aim to more profoundly understand capsid structure-function relationships and use this information to select and engineer gene therapy...
We use dsRNA viruses from the families Reoviridae (primarily orthoreoviruses and rotaviruses), Partitiviridae, and Totiviridae to study fundamental aspects of structure-function relationships in virus particles, virus particle assembly, virus-cell...
We are working to understand how cells respond to pathogens, and how these signaling pathways can be harnessed for new potential therapies to treat cancer and autoimmune diseases. Importantly, many critical aspects of the cellular response to infection...
Elucidating the Molecular Principles of Self vs Non-self RNA Discrimination by the Immune System
Correct discrimination of “self” vs “non-self” nucleic acids by the innate immune system is essential for host defense against viral infection. A failure to...
Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the...
