Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
Our laboratory is interested in the development of herpes simplex virus (HSV) vectors for cancer therapy, with the long-term goal of translating these vectors to the clinic, and strategies to target cancer stem cells. Oncolytic (replication-competent)...
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic...
1. Resistance to antiretroviral drugs
For many HIV-infected patients, the potential benefits of antiretroviral therapy are limited by emergence of drug-resistant virus. Work in my laboratory is directed towards understanding mechanisms of resistance to...
The role of Merkel cell polyomavirus in Merkel cell carcinoma
Merkel cell carcinoma is a skin cancer with a high rate of mortality. Factors that increase the risk for developing MCC include excessive exposure to sunlight, advanced age and an...
The gamma-herpesvirus Epstein Barr virus (EBV) is a master regulator of B-cell biology. EBV persistently infects >95% of adults, making it one of the most successful viruses worldwide. While EBV typically establishes a safe balance with the host, it is...
Our lab studies molecular mechanisms of HIV replication and pathogenesis, and their role in mediating pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, metabolomic, systems biology, and...
Our body is colonized by a robust and diverse ecosystem - the commensal microbiome. When mucosal pathogens infect us, they first encounter our commensals before they encounter and activate our immune response. The Gopinath lab is interested in the...
The Vandenberghe laboratory deconstructs viral evolution to improve viral vector design and use in gene therapy. We aim to more profoundly understand capsid structure-function relationships and use this information to select and engineer gene therapy...
We use dsRNA viruses from the families Reoviridae (primarily orthoreoviruses and rotaviruses), Partitiviridae, and Totiviridae to study fundamental aspects of structure-function relationships in virus particles, virus particle assembly, virus-cell...
