Our lab focuses on innate immunity to RNA viruses.
The genomes of humans and other animals harbor genes that have naturally evolved to combat viral infections and promote health. Our goal is to identify these antiviral strategies shaped by nature and...
Our laboratory is interested in the development of herpes simplex virus (HSV) vectors for cancer therapy, with the long-term goal of translating these vectors to the clinic, and strategies to target cancer stem cells. Oncolytic (replication-competent)...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic...
Research in the Engelman laboratory focuses on the integration step in the retroviral life cycle. In order to replicate, retroviruses must integrate the viral DNA (vDNA) product of reverse transcription into a host cell chromosome. In addition to the...
The role of Merkel cell polyomavirus in Merkel cell carcinoma
Merkel cell carcinoma is a skin cancer with a high rate of mortality. Factors that increase the risk for developing MCC include excessive exposure to sunlight, advanced age and an...
The gamma-herpesvirus Epstein Barr virus (EBV) is a master regulator of B-cell biology. EBV persistently infects >95% of adults, making it one of the most successful viruses worldwide. While EBV typically establishes a safe balance with the host, it is...
Our lab studies molecular mechanisms of HIV replication and pathogenesis, and their role in mediating pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, metabolomic, systems biology, and...
Our laboratory investigates Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8). KSHV has a causative role in Kaposi's sarcoma, primary effusion lymphomas and multicentric Castleman's disease, an aggressive lymphoproliferative...
