#  Joseph Sodroski 

Professor of Microbiology

 

 

 



   ![Photo of Joseph Sodroski](/sites/g/files/omnuum5516/files/styles/hwp_4_5__480x600/public/2024-09/Sodroski_Joseph_0.jpg?h=1f7c9a2b&itok=w1XH3AB_) 

 



 

 location\_on Dana Farber Cancer Institute 450 Brookline Avenue CLS Building, Room 1010 Boston, MA 02115 

 smartphone [617-632-3470](tel:617-632-3470) 

 email [joseph\_sodroski@dfci.harvard.edu](mailto:joseph_sodroski@dfci.harvard.edu) 

 laptop\_windows [Lab Website](https://www.dfhcc.harvard.edu/insider/member-detail/member/joseph-g-sodroski-md/) 

 laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Sodroski%2C%20Joseph%20G&sort=date) 

 

 



 

The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic. The laboratory studies HIV-1 entry into cells, a process that is mediated by the viral envelope glycoproteins. These glycoproteins bind receptors on the target cell and fuse viral and cell membranes. The conformational transitions of the HIV-1 envelope glycoproteins that contribute to virus entry are being characterized. The laboratory is devoted to understanding HIV-1 entry at the molecular level, and identifying and characterizing inhibitors. The interaction of small-molecule entry inhibitors and neutralizing antibodies with the HIV-1 envelope glycoproteins is being studied.

In virus-producing cells, expression of the HIV-1 envelope glycoproteins results in cytopathic effects. These toxic effects result from the membrane-fusing activity of the HIV-1 envelope glycoproteins, which results in damage to the host cell membranes. The contribution of these processes to the depletion of CD4-positive T lymphocytes in vivo is being studied.



 

 

 





 

 

- ## Field of Study
    
     [Anti-Viral Chemotherapy](/field-study/anti-viral-chemotherapy) [HIV and SIV](/field-study/hiv-and-siv) [Human and Animal Virus Replication](/field-study/human-and-animal-virus-replication) [Immunology of Viral Infection](/field-study/immunology-viral-infection) [Pathogenesis of Viral Infection](/field-study/pathogenesis-viral-infection) [Receptors and Signal Transduction](/field-study/receptors-and-signal-transduction) [Viral Vaccines](/field-study/viral-vaccines)
- ## Person
    
     [Faculty](/people/person/faculty)